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[2] Taking it with breakfast or lunch, rather than on an empty stomach, can significantly enhance bioavailability

A common protocol, for example, is to begin with about 20 mg of NAD+ (corresponding to a small volume from the vial, typically around 0.1 mL depending on concentration) administered subcutaneously and gradually increase the dose over subsequent injections up to around 100 mg per injection

Neurosci Res 6(4):321328 Fukui K, OMOI NO, Hayasaka T, Shinnkai T, Suzuki S, Abe K, Urano S (2002) Cognitive impairment of rats caused by oxidative stress and aging, and its prevention by vitamin E

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It should also serve to promote the growth of starter bacteria and deliver added functionalities like flavor generation