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Additional safety considerations include risk of dehydration and acute kidney injury, potential worsening of diabetic retinopathy with rapid glucose improvement (particularly with semaglutide), and hypoglycemia risk when combined with insulin or sulfonylureas

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Among several amino acids, L-glutamine is the most effective in promoting the release of GLP-1 via intracellular cAMP and Ca 2+ increases in GLUTag cells 38

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We conducted a randomized, double-blind, placebo-controlled multiple ascending dose phase 1 study at a single center in the Republic of Korea in adults with overweight (BMI 2530 kg/m)

Longitudinal analysis of physical function in older adults: The effects of physical inactivity and exercise training