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Adipose tissue in metabolic disease is itself an inflammatory organ, secreting cytokines (adipokines) that sustain the NF-B-driven inflammatory state that makes insulin resistance self-perpetuating

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Switching to 2.0 mL or even 1.0 mL of water for subsequent vials brings the unit count back into a manageable range

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This strategy combines the biological effects of PBM with medical devices, aiming to promote post-operative repair, reduce inflammatory responses, and inhibit KOA progression (55)