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Molloy AM, Daly S, Mills JL, Kirke PN, Whitehead AS, Ramsbottom D, Conley MR, Weir DG, and Scott JM (1997)

2011 Sep;64(9):756-60

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The finding established that the GSH redox cycle is the primary intracellular antioxidant defence system in endothelial cells against peroxide-mediated oxidative stress, and remains a foundational reference for endothelial oxidative stress research using GSH manipulation

However, modern nutraceutical science has overcome this hurdle through the development of sustained-release (SR) formulations

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