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In practice, the timeline to generic entry depends on: last relevant composition patent expiration, whether use patents survive, whether exclusivity (regulatory) extends market protection, and whether litigation blocks or delays approval of biosimilar/4th-gen analogs (depending on jurisdiction)

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When returning from injury or after a layoff period, increase training loads by no more than ten percent per week

It can develop as overweight, when the body mass index (BMI) is between 25 and 29.9 kg/m2 or as clinically defined form of obesity, when BMI exceeds 30 kg/m2

10.1016/j.jad.2014.03.041 42

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