UK guidance recommends gradual dose titration starting at 2.5 mg weekly, with regular monitoring of glycaemic control and renal function
Cortistatin has the superior mechanistic profile, with a well-defined receptor pharmacology, clear sleep-promoting mechanism through cortical synchronization, and endogenous homeostatic sleep factor properties
Incidence of ARIAs in clinical trials of monoclonal antibodies has reached up to 40% in some cohorts [539], underscoring the need for appropriate imaging protocols
Moreover, the availability of multiple effective obesity pharmacotherapies with different mechanisms of action will provide clinicians the opportunity to select treatments based on patient preference, underlying comorbidities, medication safety profile and treatment response, with an aim to achieve the individualised WL targets, improve the overall health and/or the quality of life [7]
PMID 34827158
Mites can be particularly troublesome in dry summers without irrigation
