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There are several mechanisms involved in TP53-mediated metabolic changes (158, 159)

Usefulness of Carnitine Supplementation for the Complications of Liver Cirrhosis

Patel S, Tang J, Overstreet JM, Anorga S, Lian F, Arnouk A, et al

This modulation affects blood flow to healing tissues and contributes to the peptides cardiovascular protective effects

Further, mtROS acts as a second messenger stimulating NLRP3 activation and localization to the mitochondria to promote IL-1 activation, thus inciting a proinflammatory signal in response to mitochondria dysfunction (Zhou et al., 2011

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