Furthermore, development of small molecule agonists or antagonists is often performed via binding a certain and definite site in the target molecule while PROTAC is not dependent on these certain sites as it is implemented via the efficient building of a ternary complex between the PROTAC molecule, the protein of interest and the E3 ligase
J Biol Chem (2013) 288(23):1622534
baseline liver and pancreatic enzyme levels
The Colbert Report, Episode 1017 Archived September 27, 2007, at the Wayback Machine "Elijah Wood and Stephen Colbert Compare 'LOTR' Sting Swords (VIDEO)"
Zhou S, Deng H, Zhang Y, Wu P, He B, Dai W et al (2020) Thiolated nanoparticles overcome the mucus barrier and epithelial barrier for oral delivery of insulin
The post describes pancreatitis risk as rare for both medications and for oral formulations, with similar monitoring recommended in each case