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Ischemia-reperfusion injury (IRI) IRI followed by reperfusion can induce massive cell death and inflammatory response in affected organs, resulting in severe diseases including IRI-induced heart disease, kidney diseases, lung diseases and liver diseases [242]

eClinicalMedicine 58 , 101962 (2023)

PubMed Dreno, B., Moyse, D., Alirezai, M., Amblard, P., Auffret, N., Beylot, C., Bodokh, I., Chivot, M., Daniel, F., Humbert, P., Meynadier, J., and Poli, F

[PubMed: 8633830] 58

K11-linked branched chains, for example, facilitate rapid turnover of key cell cycle regulators, whereas linkages such as K27, K29, and K33 can attenuate degradation, illustrating how chain topology fine-tunes proteolysis