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Frequent delays beyond 3 days may reduce appetite suppression and slow weight loss, so setting phone reminders can help maintain consistency

doi:10.1016/j.mce.2015.06.012

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In my practice, we approach discontinuation carefully: Gradual taper when appropriate Maintenance nutrition plan Structured exercise Continued metabolic monitoring Some patients benefit from extended maintenance therapy

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Compared to exogenous recombinant GH (somatropin), Tesamorelin preserves the physiological pulsatility of endogenous secretion, maintaining better tissue response, avoiding GH-R desensitization, and presenting a more balanced metabolic profile (glycemic neutrality vs diabetogenic effect often documented with high-dose exogenous GH)