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Therefore, a once-daily dosing is appropriate since inhibition of DPP-4 activity is sustained for a long period of time

Tirzepatide advantages in trials: Greater total weight loss, stronger HbA1c reduction, favorable body composition changes, long-term durability data Semaglutide advantages in trials: Established cardiovascular outcomes data (SELECT trial), longer real-world track record, oral formulation option Both medications: Require lifestyle changes to maximize results

Giunchi, V., Fusaroli, M., Hauben, M., Raschi, E

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