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Yes, doctors may prescribe GLP-1s off-label to manage the metabolic shifts caused by dropping hormones

There is no universal legal requirement, but clinical guidelines from the ADA and most major medical societies recommend comprehensive metabolic evaluation before initiating GLP-1 therapy

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Body composition data from the SURMOUNT-1 trial of tirzepatide show that approximately 75% of the weight lost was fat mass and 25% was lean mass 2