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[DOI] [PMC free article] [PubMed] [Google Scholar] 111.Kumar P., Liu C., Hsu J.W., Chacko S., Minard C.G., Jahoor F., Sekhar R.V

GPER and bone metabolism With accelerated global aging, the incidence of metabolic bone disease (MBD) is increasing annually and has become one of the important challenges facing public health [139]

Direct effects include increased lipolysis (fat breakdown), enhanced protein synthesis, improved glucose body function, and many body effects

Aqueous solubility facilitates transport within the blood and excretion via the kidney, while a lipophilic chelator may exhibit greater penetration of cellular membranes (including those within the central nervous system) to chelate intracellular elements

Researchers arent sure exactly why intermittent fasting lowered IGF-1 levels in this study (31)