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In September 2025, the FDA granted accelerated approval to elamipretide (under the brand name FORZINITY) for Barth syndrome, making it the first FDA-approved mitochondria-targeted therapy

The inclusion of myostatin-related signaling fragments highlights an important nuance: biological pathways that appear unattractive when targeted aggressively may yield therapeutic benefit when modulated with greater precision

Seven more submissions are currently under review by Health Canada

33 MuraoK.LiJ.ImachiH.MuraokaT.MasugataH.ZhangG.et al (2009)

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Comparisons among the three proglucagon-derived peptides showed that GLP-2 is most variable yet shows the least evidence for change in function within mammals ( Table 2 , Supplementary Figure 5 , and Supplementary Tables 7 and 8 )