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Further, the inherent limitations of studying topical dosing in murine models necessitates further studies of pharmacokinetics and efficacy in larger species, as well as ocular safety and tolerability studies

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Schneider-Helmert's double-blind study showed reduced sleep latency in the DSIP group compared to placebo (Schneider-Helmert, 1992)

The primary biomarkers traditionally employed are total serum vitamin B12 and holotranscobalamin (also known as Active B12), which represents the metabolically active fraction of B12 bound to its transport protein

Retinol forces cell turnover so newer skin surfaces faster