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A previous review of animal studies from the University of Amsterdam linked GLP-1 exposure during pregnancy to reduced foetal growth and skeletal abnormalities, and while human data is limited, the potential risks remain concerning
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According to this study, both hyperglycemia and hypoglycemia in patients with type 1 diabetes gives rise to endothelial dysfunction, oxidative stress, and inflammation and GLP-1 can be useful to counterbalance these effects
In immortalised human airway epithelial cell lines (including bronchial epithelial cells) and human alveolar epitheliallike cells, GLP-1 receptor agonists reduced epithelial stress and inflammatory signalling, including downregulation of epithelial-derived cytokines, including IL-33 and thymic stromal lymphopoietin (TSLP), both of which are implicated in epithelialmesenchymal crosstalk and fibroblast recruitment in fibrotic lung disease [66,67,68]
doi: 10.1177/19322968231223991 51 AlmoharebSNAlfayezOMAljuaidSSAlshahraniWABakhshGAlshammariMKet al
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