However, when semaglutide delays gastric emptying, naproxen exposure time to stomach tissue increases, compounding the potential for ulceration, bleeding, or severe nauseaside effects that overlap with common semaglutide tolerability issues
However, some research suggests that higher intakes, around 1.2 g/kg and up to 1.5 g/kg, for those who exercise regularly, may better support lean muscle during weight loss
November 2025, Janet Iwasa
2 So the two medications cant be swallowed together
Decreased appetite is technically a side effect but also the primary mechanism through which weight loss occurs, so most people consider it a feature rather than a bug
Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist that works by mimicking the action of the naturally occurring GLP-1 hormone