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Importantly, sleep disorders and circadian misalignment have been shown to further disrupt gut microbiota composition, leading to altered microbial metabolite profiles (Lin et al., 2024), impaired antioxidant production, and increased generation of ROS

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The next-generation of transformative peptide therapeutics is therefore likely to emerge not from novel hormone discovery, but from the systematic rediscovery and reengineering of endogenous peptidereceptor systems long considered too complex to pursue

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