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This effect may be related to the activation of AMP-activated protein kinase (AMPK) and sirtuin1 (SIRT1)/forkhead box O1 (FOXO1) pathway (Li et al., 2018

Altogether, we conclude that HSV-1 infection can enhance Keap1-dependent Nrf2 degradation, thereby disrupting cellular redox homeostasis and promoting ferroptosis

doi: 10.1111/j.1365-2710.2010.01237.x 46

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Vitamin B12 is vital in many of the bodys essential functions

Its selective receptor profile makes it particularly valuable for mechanistic investigations requiring focused pathway analysis and minimal off-target receptor interaction