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2.2.1 Effects of ACN on hepatic inflammation NF-B and Nrf2 are major transcription factors involved in the regulation of pro-inflammatory and antioxidant genes, respectively

The elution profile of the sample homogenized in BSAN buffer (blue tracing) is characterized by the presence of both the two symmetrical peaks corresponding to the GS-NEM conjugate (4.29 min and 4.95 min r.t.) and the peak corresponding to the excess of NEM (5.8 min r.t.)

The primary endpoint was the change in A1C from baseline to week 16

These are usually taken daily rather than as needed

Recently, another selective inhibitor of GLS1, CB-839 (telaglenastat), showed no significant side effects in preclinical trials and is currently undergoing full clinical trials 45