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They might do perfectly fine on a fraction of the standard dosing schedules for years, keeping their metabolic markers in check without aggressive intervention

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Pashirova TN, Zueva IV, Petrov KA, et al

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The fact that these site-specific changes are reproduced by DUB inhibition but not by proteasome inhibition 5 , highlights the distinct role of DUBs in maintaining HSPA8 chaperone activity by regulating its ubiquitylation