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Loss of Von Hippel-Lindau (VHL) tumor suppressor gene function: VHL-HIF pathway and advances in treatments for metastatic renal cell carcinoma (RCC)

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Typical symptoms include the following: Heavy or prolonged menstrual bleeding Severe, cramping period pain Diffuse pain and pressure in the abdomen Fibroids usually cause symptoms if they affect the function of the womb, for example during menstruation

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