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Unapproved peptide products, particularly those that are injected, carry significant safety risks, including contamination, infection or local tissue damage

thus, insurers need to take measures to monitor and bolster adherence whenever possible to realize the best long-term mortality and morbidity benefits of these drugs

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whether this is due to increased sensitivity of TAS2Rs to bitter compounds (producing even greater GLP-1 enhancement) or to increased sensitivity to GLP-1 effects is unclear