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These results confirm that the cardiovascular protection seen with injectable GLP-1 agonists extends to the oral formulation, an important finding that strengthens the case for offering patients a choice of delivery method based on their preferences rather than effectiveness alone

Psychopharmacology, 214(2), 515-523

Moreover, the degree and trajectory of weight loss may have differed substantially between semaglutide users and controls, particularly if weight loss in the control group was achieved through lifestyle-related approaches rather than pharmacologic treatment, but these differences could not be measured within TriNetX

Beyond weight loss The authors say these findings could have far-reaching implications for how semaglutide and similar GLP-1 drugs should be used

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Menor riesgo cardiovascular Semaglutida reduce las muertes por eventos cardiovasculares entre 15 % y 19 %