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While there's no official upper limit, doses up to 2,000 mcg can be safely used to treat B12 deficiency under medical supervision

Exploring the safety and efficacy of glutathione supplementation for skin lightening: A Narrative review

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doi:10.1097/MAO.0000000000000472 42

The steady-state concentration of glutathione in women depends on the strength of the activation of GCL and GPX and is quite homeostatic over a wide range of activations

PMID: 12428286