"Mary Shorb Lecture in Nutrition"
At the adipose tissue level, the combined GIP and GLP-1 agonism reduces M1 macrophage infiltration and pro-inflammatory cytokines such as leptin, increases adiponectin, and enhances insulin sensitivity, thereby improving adipocyte dysfunction.39 GIP additionally increases the storage capacity of adipose tissue, which lowers the likelihood of ectopic fat deposition and reduces the extent of visceral fat.1,5,39 Furthermore, it has demonstrated neuroprotective effects and promotes bone formation1 (Table 2)
Chem Pharm Bull 67(7):675689 Morris HR, Spillantini MG, Sue CM, Williams-Gray CH (2024) The pathogenesis of Parkinsons disease
It helps the liver to dispose of harmful substances and metabolic waste and protects DNA and cells from oxidative stress caused by free radicals
Do not self-escalate dosage without medical guidance
The pathophysiology of chronic constipation in diabetes is multifactorial, involving microvascular, neuropathic and myopathic changes
