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Interestingly, it was shown that this axis contributes to T-cell anergy within tumor draining lymph nodes and that PD-1/PD-L1 interactions within tumor draining lymph nodes can be used as a prognostic marker to determine melanoma treatment outcomes (165)

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The models were divided into a test group exposed to the peptide, and a control group (who did not receive the substance)

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ClinicalTrials.gov (ClinicalTrials.gov identifier NCT00044213)

Subsequently, treatments with eye drop preparations containing hylauronic acid with or without GSH-C4 (25 L/well and 50 L/well of eye drop products) was initiated both in the absence and presence of Lipopolysaccharide (LPS) (1 g/mL) or hydrogen peroxide (H 2 O 2 ) (25 M) added to induce stress conditions