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Phase 2 body composition data from the Lancet Diabetes and Endocrinology substudy showed retatrutide achieving fat mass reductions of 15.2% at the 4mg dose, 26.1% at 8mg, and 23.2% at 12mg, while the proportion of lean mass loss relative to total weight loss remained comparable to other GLP-1 compounds

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GLP-1 medication, protein guidance, and exercise programming are included in the standard weight loss program

Strategies to bypass or disrupt the BBB are being explored, such as nanotechnology [7, 8], to improve drug delivery to the brain tumor

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