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The GSH depleting drugs switch the redox state towards an oxidant condition provoking oxidative/nitrosative stress and inflammation, which lead to apoptosis and/or autophagy of the enterocytes

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PMID: 8053578 [DOI] [PubMed] [Google Scholar] 57.Twersky RS, Goel V, Narayan P, Weedon J (2014) The risk of hypertension after preoperative discontinuation of angiotensin-converting enzyme inhibitors or angiotensin receptor antagonists in ambulatory and same-day admission patients

Basically, we are reacting to health issues as they occur instead of actively trying to prevent them

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