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Recent observational data suggests that patients combining bariatric surgery with GLP-1 therapy achieve sustained weight loss outcomes superior to surgery alone

10.1111/j.1460-9568.2006.04707.x Eur

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Therefore, we reviewed available literature describing the versatile effects of SGLT-2i on CNS, with the aim of establishing the actual role played by SNS and central physiology of SGLT-2i with regards to the mechanism of cardiovascular benefits