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Additionally, the oral bioavailability observed in animal models makes the compound attractive for potential clinical development

Both in vivo and in vitro experiments have demonstrated that the GLS1 inhibitor BPTES normalized the effector function of CD4 + T cells and effectively improved the dysregulation of exocrine glands in Sjogrens syndrome (SS) (98)

10.1038/nm.4232 10 DorofeyevaN

Zhang R, Zhang L, Li Z, Zhang P, Song H, Yao DA, Cao J, Zhang JJ (2022) Green tea improves cognitive function through reducing AD-pathology and improving anti-oxidative stress capacity in Chinese middle-aged and elderly people

Bottom line : CagriSema could be the most effective weight loss injection yet (beating tirzepatide in early data), but wait for approval

Vitamin B12 injections are used to treat these by raising B12 levels and possibly fixing some nerve damage