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Although no significant change was observed in the bone formation marker P1NP, the semaglutide group showed a significant increase in the bone resorption marker CTX and a reduction in areal BMD at both the lumbar spine and total hip

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doi: 10.1152/ajpheart.00486.2019

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Semaglutide came off the shortage list a year ago, but some companies have continued to provide the drug to patients under exceptions for 'personalised' treatments under a framework known as Section 503A