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Effects of proteins, blood cells and glucose on the viscosity of cerebrospinal fluid

Cid-Arias L, et al

Reactive oxygen species dependent hypertension in dopamine D2 receptor-deficient mice

But the long-term safety is completely unproven , and there are plausible mechanisms by which things could go wrong (such as promoting tumor growth or causing unwanted tissue changes)

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Yes, shaking can damage the delicate peptide chains, reducing the compounds effectiveness