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Furthermore, NGF and its receptors are expressed, and in many cases, modulated during stress in non-neural tissues, such as epithelial cells, fibroblasts, lymphocytes, activated macrophages, the pancreas, the heart and the liver ( Previous in vivo and in vitro studies have revealed a role for NGF in the activation of the antioxidant response in the CNS in regions such as the cerebellum ( On the other hand, the p75 NTR receptor has been reported to either induce or prevent apoptosis upon oxidative insult in both in vivo and in vitro models

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