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[Note: RCT meta-analysis data (80 RCTs, 107,860 participants) from Wang et al

However, despite its efficacy, high dropout rates from the study were seen due to side effects

In rare cases, semaglutide may cause more serious side effects that require immediate medical attention

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Another study determined that GLP-1 could restore insulin secretion via modulation of actin polymerization, independent of a recently identified role for the mammalian target of rapamycin complex 2 (mTORC2) in actin modulation and insulin sensitivity 9