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Semaglutide can cause frequent urination through several mechanisms, including osmotic diuresis, increased fluid intake, changes in hormone regulation, and adjustments in kidney function

In clinical research, it acts on three hormone pathways involved in appetite and energy balance: GLP1 (glucagon-like peptide1), GIP (glucose-dependent insulinotropic polypeptide), and glucagon receptors

It is also instrumental in helping to detoxify or cleanse the liver of the toxins that the liver normally removes from the circulating blood

No pharmacological overlap washout is needed because both drugs are GLP-1 agonists, though re-escalating through the full semaglutide dose ladder is recommended to minimize GI side effects

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