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Another meta-analysis indicated that while there was strong evidence for elevated serum UA as a protective factor for PD, the influence of gout on PD is far weaker 19

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Malabsorption Issues: This is the most prevalent reason for B12 deficiency, even for those with B12-rich diets

This includes upregulation of antioxidant enzymes (superoxide dismutase, catalase) that protect against oxidative damage, enhancement of growth factor expression (TGF-, VEGF, PDGF) that supports tissue repair, and suppression of inflammatory gene expression that contributes to chronic skin degradation

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