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References Blundell, J., Finlayson, G., Axelsen, M., et al

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Medications like semaglutide and tirzepatide part of the GLP-1 group, have become popular because they assist with weight loss, control hunger, and regulate blood sugar levels

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These results suggested the possibility of GLP-1 as a treatment for diabetes, but limitations for therapeutic utility existed as endogenous GLP-1 had a short half-life in plasma of 1 to 2 minutes, degraded by the dipeptidyl-peptidase 4 (DPP-4) enzyme [13]

10.1038/nature00965 Nature 74 RidderstraleM.DegermanE.TornqvistH