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Work to minimize environmental and lifestyle contributors

Given the high rate of gastrointestinal tolerability challenges and resultant discontinuation that is characteristic of GLP-1 therapy, we believe that a personalized approach to GLP-1 titration and dosing, including a mealtime bolus option, would give patients an opportunity to reach their treatment goals, while experiencing easier therapy initiation and a more tolerable maintenance regimen, said Jeb Besser, CEO of Modular Medical.

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Your doctor needs accurate information about your regular metabolic state, not a best-case scenario achieved through unsustainable short-term behavior changes

GLP-treatment could start to become highly personalized: As Horn put it to me, somebody with obstructive sleep apnea may still want to take Zepbound because that drug has proven effective for both that condition and weight loss at the same time

This suggests that early and late plasticity may require translation that depends on proteins with different functions