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First, in the absence of Albumax and drug, PS exposure of erythrocytes slowly increased over time, both in Ringer solution (24-fold increase after 48 h, p =0.0011) and in iRPMI (6.4-fold increase after 48 h, p =0.0068)
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A subsequent isolation and amino acid sequence determination of two homogeneous polypeptides from purified non-suppressible insulin-like activity factors (158160) established the current designation of these molecules as insulin-like growth factors (IGFs) 1 and 2 (161)
