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It activates receptors in the central nervous system, particularly MC3R and MC4R

Os benefcios mais bem documentados nos estudos pr-clnicos incluem: acelerao da cicatrizao de tendes e ligamentos (com melhora das propriedades biomecnicas), proteo da mucosa gstrica contra AINEs e lcool (reduo de 78% da superfcie ulcerosa em modelos animais), estimulao da angiognese via VEGF, e efeitos neuroprotetores em modelos de leso cerebral

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A.LinC.-H.YangS.-C.AlalaiweA.FangJ.-Y

First, these agents promote clinically meaningful weight loss

To explore whether LS GLP-1R neuronal activity acts as negative or positive valence, we implemented optogenetic activation by expressing channelrhodopsin (ChR2-mCherry) selectively in LS GLP-1R neurons (Figure 5I)