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They usually contain seven conserved Cys residues, five in the N-terminal domain which include four iron-sulfur (Fe-S) cluster ligands and a catalytic residue and two in the GRX-like domain (Figure 2 and Supplementary Table 2)

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These findings indicate that both A-CDs and AA-CDs can significantly inhibit t-BHP-induced ECM degradation in chondrocytes, with AA-CDs demonstrating a more pronounced effect

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