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Not only did Yamanaka demonstrate that the four proteins, called Yamanaka factors, could turn adult cells into stem cells, but importantly, his work demonstrated that a reset of epigenetic information is possible

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Furthermore, 5-Amino-1MQ has been explored for its potential in improving insulin sensitivity a critical factor in combating metabolic dysfunction

Due to the continuous exposure to occlusal forces and periodontal microorganisms, alveolar bone possesses a unique immune microenvironment distinct from the long bones, with more frequent interactions between monocytes/macrophages and MSCs (Lin et al., 2021)