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Among xenobiotics metabolized by CYP2E1 are acetaldehyde, acetaminophen, acrylamide, aniline, benzene, butanol, carbon tetrachloride, diethylether, dimethyl sulfoxide, ethyl carbamate, ethylene chloride, halothane, glycerol, ethylene glycol, N -nitrosodimethylamine, 4-nitrophenol, pyrazole, pyridine, and vinyl chloride

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Though the mechanism(s) underlying the decreased risk of incident and recurrent CUD with semaglutide is unclear, several mechanisms could be involved

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Izgelov D, Regev A, Domb AJ, Hoffman A