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However, it is important to note that erythrocytes generate ROS primarily as a result of (i) hemoglobin oxidation, which can be considered as an iron-mediated Fenton reaction, (ii) the activity of NAPDH oxidase and (iii) xanthine oxidoreductase, while in nucleated cells ROS are mainly generated in the mitochondrial electron transport chain

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Franasiak JM, Holoch KJ, Yuan L, et al

G., Gade, P

Oral semaglutide Nausea Abdominal pain Loss of appetite (can be more gradual) Diarrhea Injectable semaglutide Nausea Vomiting Constipation Potential injection site reactions Appetite suppression may feel stronger/faster Everyone reacts differentlyyour provider can help manage side effects during the adjustment period

J Neurol (2022) 269(2):54176