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[2] That work reported a long half-life on the order of 159195 hours (about 78 days) consistent with once-weekly dosing, and it provided the first human safety and tolerability read on the cagrilintide-plus-incretin concept that later became CagriSema

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While the study volunteers were older adults, who may have a specific vulnerability to lower levels of B12, co-first author Alexandra Beaudry-Richard, MSc, said that these lower levels could impact cognition to a greater extent than what we previously thought, and may affect a much larger proportion of the population than we realize. Beaudry-Richard is currently completing her doctorate in research and medicine at the UCSF Department of Neurology and the Department of Microbiology and Immunology at the University of Ottawa