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Pre-specified outcomes The primary outcome was defined as the annual rate of acute healthcare utilization (number of events per year of follow-up): calculated as the sum of urgent care visits, Emergency Department visits, and hospitalizations divided by the duration of follow-up

The study period on medication or placebo following the lifestyle intervention is 72 weeks (84)

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This activation promotes the secretion of interleukin-10 (IL-10) and transforming growth factor beta (TGF-) by Treg, ultimately inhibiting the anti-tumor activity of T cells

Researchers also observed lower risk for PE (HR = 0.78