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Although many clinical trials in COPD include patients with limited real-world applicability, the GOLDEN 3 and 4 studies were prospectively designed to include patients who had pre-existing cardiovascular disease (CVD), cardiovascular (CV) risk factors, and background long-acting 2 -agonist (LABA) therapies
10 Comparison of the phenotype of these IR-deficient mice with those of IGF-1R knockout mice suggests that IR and IGF-1R have distinct, but partially overlapping, physiological functions
The cell pellet was resuspended in ice-cold 100 mM Tris, pH 7.6, centrifuged again, and finally resuspended in 1 mL of the same buffer
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