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In each set, the time course is followed by the change from baseline (mean of days 3 to 1) to the mean of days 1-3, 7-9, and 18-20, as indicated

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Similarly, supplementation of RPM (Smartamine) for Holstein multiparous cows during the transition period followed by the removal of RPM supplementation until day 72 postpartum, showed a decrease in global DNA methylation compared to cows that did not receive RPM supplementation during the entire period of evaluation (Acosta et al., 2016)