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doi: 10.7326/0003-4819-132-4-200002150-00004 62 GluvicZSudarETicaJJovanovicAZafirovicSTomasevicRet al

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NR2B, N-methyl-D-aspartate receptor 2B subunit

During the process of ER stress, UPR sensors separate from chaperone proteins, such as GRP78 and PDI, and then become phosphorylated, which activates CHOP and apoptotic proteins, such as caspase-12, to induce apoptosis 41